Centro de Biotecnología y Genómica de Plantas UPM – INIA
> About Us
Plants provide a fascinating example of how to build to rebuild. Because they cannot run or escape, plants evolved regenerative, de novo organogenesis potential which is manifested through self-organization of cells and tissues. Coordinated patterning of plants requires responses to numerous growth substances, called phytohormones. Among those, a small signaling molecule auxin plays a remarkable role in coordinating plant architecture such as meristem size, flower, and leaf positioning, root growth and plant response to environmental cues. Our focus is to mechanistically understand the design principles of hormone signaling circuits in plants that shape plant architectures. To achieve these goals we travel forward and backward between predictive computer models and quantitative biology experiments answering the following questions:
How does an individual plant cell contribute to the dynamic collective behavior of plant tissue?
How dynamic auxin cues communicated between adjacent cells provide a principal driving force for self-organized multicellular patterning?
How dynamic environmental cues would impact on such self-organization manifested by patterns of spatiotemporal oscillations and cell polarity establishment?
To find answers to these intriguing questions, we use the combination of multilevel computer model simulations, synthetic biology experiments, and microfluidics. Currently, the lab employs a number of projects that access design principles of patterning mechanisms in plants that include organogenesis, hormone signal processing, and cell polarity dynamics.
Our research is funded throughout a number of funding agencies and institutions